Newcastle University said it expected to see the rise in cases in light of soaring daily coronavirus figures released by the Department of Health.
A spokesman said the institution feels confident it has “appropriate measures” in place to protect those enrolled at the university, as well as the wider Newcastle community.
In a statement, Newcastle University said: “This data represents students and staff within Newcastle city with the overwhelming majority of cases from social and residential settings.
“We expected to see cases rise in light of the increase in cases both locally and nationally and all HE institutions have to manage this on an ongoing basis.
“We feel confident that we have appropriate measures in place to protect us all while we are on campus and to reduce the potential for transmission in our community.
“We are reminding our students and staff that we can help keep each other keep safe by following the guidelines and to remember the hand, face and space message.”
Hundreds of students at Northumbria University also tested positive for the virus just days after students were pictured breaking the Rule of Six on campus.
A further 770 people are infected at Newcastle-upon-Tyne, with just 10% of those showing coronavirus symptoms in the lead up to testing.
Boris Johnson imposed the Rule of Six last month in a bid to stop households mixing with each other in large groups.
The Prime Minister also enforced a 10pm curfew, which saw pubs, bars and restaurants close at 10 to stop the spread of coronavirus.