The 61-year-old phlebotomist was randomly attacked on October 6, and the assailant is still at large.
At around 6.15am Helen Jones was on her way to work and walked towards her car in Pennsylvania.
She was then confronted by a stranger who splashed acid on her face, reports ABC news.
He daughter, Aneesha Summerville said: “There was a man there and he was like ‘Hey, are you good?’ As if he was inquiring about her safety making sure she was okay.
“And when she looked up to say ‘yes,’ he threw the stuff in her face and ran off … It’s devastating.”
After the attack, Ms Jones began to scream and rushed to her neighbour for help.
Dorothy Hannibal, her neighbour, spoke to WPVI and said: “I just heard a lot of screaming and she was banging on her door trying to get in.”
Ms Hannibal has been her neighbour for more than 20 years.
Terrified Ms Jones was rushed to Temple University Hospital where she was placed in critical condition and she is currently recovering.
Inspector Michael McCarrick of the Philadelphia Police Department told WPVI : “No previous exchange, no problems with anybody. Just a complete random incident.
“If nothing happened in 20 years, the odds are nothing will happen again for 20 years. But with that we still have to conduct our investigation.”
An investigation into the substance concluding the chemical was chlorosulfuric acid, which burned Ms Jones’ lips, tongue and eyes.
“[The doctors] just said that she’s blind. They couldn’t tell us if she would get her vision back or not,” Ms Summerville told WPVI.
“[She] didn’t know him. It was totally unexpected. She saw his eyes. If she was able to see him again she would know his eyes.”
The attacker had been wearing a mask at the time of the ordeal.
A GoFundMe page has been set up for Ms Jones to help cover medical expenses.
She was very independent one moment, and the next moment we have to make sure we are around to make sure she’s not knocking into anything or she’s not going to get hurt,” said Ms Summerville.
“One day you’re independent and living your life and the next moment you’re totally dependent on people. I just hope somebody comes forward so justice can be done for her.”
Police are still searching for the attacker.